Bibliograph

Organophosphonate caused cardiac toxicity, action potential dynamics in atrial tissue

Type

Label

Organophosphonate caused cardiac toxicity, action potential dynamics in atrial tissue

Language

eng

Bibliography note

Includes bibliographical references (p. 11-12)

resource.governmentPublication

federal national government publication

Illustrations

illustrations

Index

no index present

Literary Form

non fiction

Main title

Organophosphonate caused cardiac toxicity

Nature of contents

bibliographydictionaries

Oclc number

227996336

Series statement

ARL-TR, 2738

Sub title

action potential dynamics in atrial tissue

Summary

Highly effective treatments for the effect of organophosphonate and organophosphate (OP) nerve agents have eluded the medical community. It is known that acetylcholine overload is one of the effects of OP toxicity, but the cellular processes leading to cardiac toxicity are still incompletely understood. This study details high performance computer simulations of the electrophysiology in atrial toxicity. It shows that hyperkalemia of the tissue, one of the manifestations of OP intoxication, promotes the processes leading to reentry, a recursor of atrial fibrillation. Then, we demonstrate that changes in two of the potassium membrane currents, i(sub Kr) and i(sub Ks), can modulate the reentry process. This suggests that Class III anti-arrhythmic agents that primarily block these currents in the cardiac cells are important candidates for therapeutics of OP poisoning

Contributor

Creator